Diabetes And Drug Treatments Discussion Paper
Diabetes And Drug Treatments Discussion Paper
Thank you for shedding light on new modalities to treat diabetes type 2 and self-monitoring techniques. Diabetes type two arises from a resistance to insulin and relative deficiency of the pancreatic beta cell, which are produced within the first few years of our life, if your body fails to produce enough beta cell and start to develop insulin resistance later in life, the beta cells works too hard and eventually die, thus end up with type 2 diabetes. Pilla et al. (2018) describe that, in addition to C-peptide test, islet cell antibodies evaluation could help differentiate between type 1 and type 2; islet cell antibodies are auto-antibodies directed at the pancreas found in more than 95% of patients with type 1 diabetes at diagnosis and are usually persistent therefore forming the better difference between the two form of diabetes. Diabetes And Drug Treatments Discussion Paper
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Metformin a biguanide derivative, besides anti-diabetic properties has also other benefits. Lv and Guo (2020) describe the additional unexpected but effective scientific proven roles of metformin like exerting a strong effect on numerous cancers by inhibiting growth, survival and metastasis of different types of tumor cells such as breast, liver, bone, pancreas, endometrial, colorectal, kidney, and lung cancers. In the hepatic system, the liver plays a critical role in glucose homeostasis and lipid metabolism, hence the main target organ of metformin. When a dysfunction arises, it can lead to complications such as diabetes, non-alcoholic fatty liver disease, cirrhosis, non-alcoholic hepatitis, and hepatocellular carcinoma (HCC).Metformin is safe in patients with cirrhosis and decreases the risk of death and development of HCC (Lv & Guo, 2020). Among non-diabetic individuals, metformin has shown to exert weak but beneficial effects on weight loss. Metformin improves insulin sensitivity and decreases fasting insulin levels in patients with abnormal glucose metabolism. It is the treatment of choice for pregnant women with gestational diabetes (GDM), and polycystic ovarian syndrome (PCOS) (Lv & Guo, 2020)Diabetes And Drug Treatments Discussion Paper. However, besides its anti-diabetic effects, it has been proven that patients taking metformin for more than 10 years have a higher risk of beta cell failure and insulin resistance. Diabetes And Drug Treatments Discussion Paper
References
Lv, Z., & Guo, Y. (2020). Metformin and its benefits for various diseases. Frontiers in endocrinology, 11, 191.Doi: 10.3389/fendo.2020.00191.
Pilla, S. J., Maruthur, N. M., Schweitzer, M. A., Magnuson, T. H., Potter, J. J., Clark, J. M., & Lee, C. J. (2018). The role of laboratory testing in differentiating type 1 diabetes from type 2 diabetes in patients undergoing bariatric surgery. Obesity surgery, 28(1), 25-30. Doi: 10.1007/s11695-017-2804-5.
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Three Objectives:
List three differential diagnoses based on the information provided
Formulate a treatment plan for the primary diagnosis
Provide educational and health promotion tips
Patient Information
Initials: Z.Z
Age: 66 years old
Gender: female
Race: African American
Historian: patient
1
1
Subjective Data
Chief complaint (CC): Increasing tiredness, urination, thirst and hunger.â€
History of Present Illness (HPI): The patient ZZ is a 66-year-old African American female who presents to the clinic with complaints of increasing tiredness, hunger, and thirst. She reports that she has been feeling like this for months and thought it was due to exhaustion from her volunteering work. She tries taking it slow, resting and sleeping more, but she still feels the same or even worst. Her son asked her to see the provider after she started having intermittent blurry vision two weeks ago; he thinks it might be something else going on. She denies chest pain, shortness of breath, palpitation, cough, weight loss and fever. Diabetes And Drug Treatments Discussion Paper
Allergies: No known food or drug allergies
Current medications:
Hydrochlorothiazide 12.5 mg daily
Lisinopril 10 mg daily
Atorvastatin 20mg daily
Past Medical History (PMH):
Childhood illnesses: No significant childhood illness
Adult illnesses: Hypertension, Hyperlipidemia
Immunization: Influenza 09/2021, Tdap booster 06/2018, Shingles 02/2019. Covid-19 booster 01/2022, Pneumococcal 08/2019
Surgeries: No past surgical history
Family Medical History
Father – deceased at 60yr had hypertension, stroke, and heart attack
Mother – Living – has hypertension and diabetes type 2
Son – alive and healthy
Social history:
Occupation – a retired teacher
Major hobbies – enjoys reading, watching TV and volunteering in church or soup kitchen
Family status – Divorced with one son who lives nearby.
Tobacco – never smoked or used an illicit drug
Alcohol use – one glass of red wine once or twice a week
Living environment – lives in a one-bedroom apartment
Exercise- once or twice a week
Diet –loves to eat out or order in
Review of Systems:
General: report tiredness, fatigue
HEENT;
Head: denies headache or dizziness.
Eyes: report intermittent blurry vision, denies pain or visual loss
Ears: denies hearing loss or difficulty, pain, or discharge.
Nose: denies runny nose, sneezing, nasal drainage, or nasal congestion
Throat: denies sore throat, dryness, and hoarseness
Cardiovascular: denies chest pain or palpitation
Respiratory: denies shortness of breath or difficulty breathing
Gastrointestinal: denies abdominal pain, diarrhea or constipation, nausea, and vomiting
Genitourinary: reports increased frequency and nocturia, denies dysuria, hematuria, or urine incontinence
Musculoskeletal: denies joint pain, swelling and stiffness
Skin: denies rash or itching. Diabetes And Drug Treatments Discussion Paper
Neurological system: denies tremors, seizures, vertigoThree Objectives:
Psychiatric: denies anxiety, depression, impaired concentration, and psychosis.
Endocrine: report increased thirst and hunger; denies heat or cold intolerance
Hematology: denies abnormal bleeding
Objective data
Vital signs: Temp: 36.2, HR: 80, BP: 135/76, RR: 18, O2 sat.97%, 0/10
Height: 70 inches, Weight: 190lbs, BMI: 27.3 kg/m2
Physical Examination:
General: the patient is pleasant and appropriate, well-groomed, and no acute distress noted
HEENT:
Head: Normocephalic
Eye: PERRLA, EOM’s intact and symmetric, the sclera is white, no discharge, peripheral vision grossly intact,
Ear: hearing grossly intact. canals clear with no cerumen, tympanic membranes intact, pearly gray, intact with light reflex
Nose: nasal mucosa reddened and moist without obvious drainage
Throat: oropharynx pink and moist
Neck: Supple, trachea midline
Respiratory: Symmetrical with respiration, lungs clear to auscultation, no rhonchi, stridor, wheezing, or crackles
Cardiovascular: the heart is normative at the 5th ICS. Normal sounds S1 and S2 are present without murmurs and pericardial rub. Peripheral arterial pulse is present and normal. There are no palpable bruits
Abdomen: soft, benign, non-tender, normal bowel sounds in all quadrants
Genitourinary: deferred
Rectal: deferred
Skin: no lesions or rashes.
Musculoskeletal: no joint pain and tenderness
Neurological: speech clear and coherent, alert and oriented to person, place, time and situation
Psychiatric: appropriate mood and affect. Maintained good eye contact throughout the interview and examination.
Diagnostic Testing and Results:
CBC- to rule out infection
CMP- to check blood sugar level
Glycated hemoglobin testing (A1C) – to assess the patient average blood sugar level in the past 3 months
Lipid panel – to check cholesterol and triglycerides levels
Thyroid-stimulating hormone (TSH) – to assess thyroid function
Random blood glucose test – to check blood sugar level
Urine Analysis (dipstick UA) – to rule out infection (UTI)
Results:
WBC – WNL
Glucose – 118 mg/dL (high)
A1C – 7.0 %
Total cholesterol – 205 mg/dL
LDL – 110 mg/dL
HDL – 100 mg/dL
TSH – 4.9 mIU/L
Glucose test – 200 mg/dL
UA – ++ Glucose 0.9 mmol/L; no leukocytes
Assessment
Primary diagnosis:
Type 2 diabetes E11.9- in this type of diabetes, the body does not make enough or use insulin well; that is, the pancreas does not produce enough insulin, or the cells are resistant to insulin, thereby taking in less sugar (Abrilla et al., 2021). It is considered adult-onset diabetes because it is more common in middle-aged and older adults. Its symptoms include tiredness, increased hunger or thirst, unplanned weight loss, frequent urination and blurred vision ( Abrilla et al., 2021). The risk factor includes being overweight or obese, lack of physical exercise, or having a family history of diabetes (Martenstyn et al., 2020). The patient is diabetic base on the labs above, especially the AIc, which indicates the average blood sugar level for three months. The patient has type two diabetes instead of type one because of her age (older), is overweight, has symptoms that appear gradually, and has a family history (Abrilla et al., 2021)Diabetes And Drug Treatments Discussion Paper.
Differential diagnosis:
Type 1 Diabetes mellitus E10.9: in type one diabetes, the body’s immune system destroys the cell that produces insulin, thereby preventing the pancreas from making insulin (Leslie et al., 2021). Its symptoms are similar to type 2 diabetes, which are increased thirst and urination, hunger, blurred vision, fatigue and unexplained weight loss (Sawyer et al., 2022). It is considered Juvenile diabetes because it is primarily diagnosed in children or teens (Sawyer et al., 2022). Its symptoms develop suddenly, but adults with type 1 diabetes have a longer symptomatic period than children and teens because their loss of insulin secretory capacity usually is less pronounced (Leslie et al., 2021). Though the presentations are the same, the patient is less likely to have type one diabetes due to her age, onset, and history.
Hyperthyroidism E05.0- in hyperthyroidism, the thyroid gland makes more thyroid hormones than the body needs. Excess thyroid hormone production speeds up the body’s metabolism leading to overactive function (Kravets, 2018). The symptoms of hyperthyroidism tend to come on slowly and vary from person to person; they include excess thirst or increased appetite, fatigue, and rapid or irregular heartbeat (Sharma et al., 2020). It is more common in women and patients older than 60 (Sharma et al., 2020). Hyperthyroidism symptoms are similar to other diseases like type 2 diabetes; therefore, tests like TSH must be done to confirm the diagnosis (Sharma et al., 2020). The patient’s TSH level is WNL, which refutes the hyperthyroidism diagnosis.
Plan
Consults:
Referred to a dietitian to help with diet
Referral to a certified diabetes educator for more information
Referred to an ophthalmologist for a yearly comprehensive eye examinations
Pharmacological management:
Prescribe Metformin 500 milligrams (mg) two times a day taken with the morning and evening meals. Side effects are nausea, abdominal pain, bloating or diarrhea
Prescribe Atorvastatin 40mg daily; take two 20mg pills or one 40mg
Non-pharmacological management;
Monitor blood glucose twice a day, morning and at bedtime, and keep daily logs for follow-up visits.
Do daily foot check to assess for any cuts, sores, blisters, or other changes to the skin or nails?
Engage in routine physical exercise at least three days per week; activities like brisk walking or riding a bike can help improve glucose levels in older people with diabetes.
Eat a smaller portion of a healthy diet that includes fruits, vegetables, whole grains, beans, nuts and seeds.
Do not skip a meal and monitor calorie intake.
Monitor for hypoglycemia’s signs and symptoms, including diaphoresis, tachycardia, shakiness, difficulty concentrating, slurred speech, and seizure.
The goal is to lose at least 10 lbs. in 6 months, which will result in better control of blood sugar levels. Diabetes And Drug Treatments Discussion Paper
Health Promotion:
Monitor A1C every three months
Annual physical and routine labs
Continue taking annual flu shot and any Covid-19 booster base on CDC recommendation
Follow CDC guidelines for Covid-19
Annual eye and dental exam
Follow up’;
Follow up in two weeks to assess response to treatment or sooner if needed
Schedule A1C lab in 3 months
Discussion questions
Which test is used to differentiate between type 1 and type 2 diabetes?
What other recommendations, treatments or teaching will you provide for the patients?
What are the complications of type 2 diabetes? Diabetes And Drug Treatments Discussion Paper
References
Abrilla, A. A., Pajes, A. N. N. I., & Jimeno, C. A. (2021). Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Diabetes Research and Clinical Practice, 178. https://doi.org/10.1016/j.diabres.2021.108824
Al-Dwaikat, T. N., Rababah, J. A., Al-Hammouri, M. M., & Chlebowy, D. O. (2021). Social support, self-efficacy, and psychological wellbeing of adults with type 2 diabetes. Western Journal of Nursing Research, 43(4), 288–297. https://doi.org/10.1177/0193945920921101
Kravets, I. (2018, March 1). Hyperthyroidism: diagnosis and treatment. American Family Physician, 93(5), 363.
Leslie, R. D., Evans-Molina, C., Freund-Brown, J., Buzzetti, R., Dabelea, D., Gillespie, K. M., Goland, R., Jones, A. G., Kacher, M., Phillips, L. S., Rolandsson, O., Wardian, J. L., & Dunne, J. L. (2021). Adult-Onset Type 1 Diabetes: Current Understanding and Challenges. Diabetes Care, 44(11), 2449–2456. https://doi.org/10.2337/dc21-0770
Martenstyn, J., King, M., & Rutherford, C. (2020). Impact of weight-loss interventions on patient-reported outcomes in overweight and obese adults with type 2 diabetes: A systematic review. Journal of Behavioral Medicine, 43(6), 873–891. https://doi.org/10.1007/s10865-020-00140-7
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Sawyer, B., Hilliard, E., Hackney, K. J., & Stastny, S. (2022). Barriers and Strategies for Type 1 Diabetes Management Among Emerging Adults: A Qualitative Study. Clinical Medicine Insights: Endocrinology & Diabetes, 1–10. https://doi.org/10.1177/11795514221098389
Sharma, S., Mudgal, S., & Mandal, A. (2020). Thyroid disease in older people: Nursing perspectives. Thyroid Research & Practice, 17(3), 110–117. https://doi.org/10.4103/trp.trp_25_20 Diabetes And Drug Treatments Discussion Paper