Advanced Pharmacology Exam Assignment Papers.

Advanced Pharmacology Exam Assignment Papers.

 

Question 1.1. Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: (Points : 1) Advanced Pharmacology Exam Assignment Papers.

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a. A need to monitor drugs metabolized by 2D6 for toxicity

b.Increased dosages needed of drugs metabolized by 2D6, such as the SSRIs

c. Decreased conversion of codeine to morphine by CYP 2D6

d.The need for lowered dosages of drugs, such as beta blockers

Question 2.2. Rifampin is a nonspecific CYP450 inducer that may: (Points : 1)
a.Lead to toxic levels of rifampin and must be monitored closely

b.Cause toxic levels of drugs, such as oral contraceptives, when co-administered.Advanced Pharmacology Exam Assignment Papers.

c.Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure

d. Cause nonspecific changes in drug metabolism

Question 3.3. Inhibition of P-glycoprotein by a drug such as quinidine may lead to: (Points : 1)
a.Decreased therapeutic levels of quinidine

b. Increased therapeutic levels of quinidine

c.Decreased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination

d. Increased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination

Question 4.4. Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: (Points : 1)
a. Toxic levels of warfarin building up.Advanced Pharmacology Exam Assignment Papers.

b.Decreased response to warfarin

c.Increased risk for significant drug interactions with warfarin

d.Less risk of drug interactions with warfarin

Question 5.5. Pharmacogenetic testing is required by the Food and Drug Administration (FDA) prior to prescribing: (Points : 1)
a. Erythromycin

b.Digoxin

c. Cetuximab

d.Rifampin

Question 6.6. Patients who have a poor metabolism phenotype will have: (Points : 1)
a.Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug

b.Accumulation of inactive metabolites of drugs

c.A need for increased dosages of medications

d. Increased elimination of an active drug

Question 7.7. Ultra-rapid metabolizers of drugs may have: (Points : 1)
a. To have dosages of drugs adjusted downward to prevent drug accumulation.Advanced Pharmacology Exam Assignment Papers.

b.Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure

c.Increased elimination of active, nonmetabolized drug

d. Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug

Question 8.8. When melatonin is used to induce sleep, the recommendation is the patient: (Points : 1)
a.Take 10 mg 30 minutes before bed nightly

b.Take 1 to 5 mg 30 minutes before bed nightly

c.Not take melatonin more than three nights a week

d. Combine melatonin with zolpidem (Ambien) for the greatest impact on sleep

Question 9.9. Valerian tea causes relaxation and can be used to help a patient fall asleep. Overdosage of valerian (more than 2.5 gm/dose) may lead to: (Points : 1)
a.Cardiac disturbances.Advanced Pharmacology Exam Assignment Papers.

b.Central nervous system depression

c.Respiratory depression

d.Skin rashes

Question 10.10. The standard dosage of St John’s Wort for the treatment of mild depression is: (Points : 1)
a. 300 mg daily.Advanced Pharmacology Exam Assignment Papers.

b. 100 mg three times a day

c.300 mg three times a day

d. 600 mg three times a day

Question 11.11. Licorice root is a common treatment for dyspepsia. Drug interactions with licorice include: (Points : 1)
a.Antihypertensives, diuretics, and digoxin

b.Antidiarrheals, antihistamines, and omeprazole

c.Penicillin antibiotic class and benzodiazepines

d.None of the above

Question 12.12. Patients should be warned about the overuse of topical wintergreen oil to treat muscle strains, as overapplication can lead to: (Points : 1).Advanced Pharmacology Exam Assignment Papers.
a.Respiratory depression

b.Cardiac disturbance

c.Salicylates poisoning

d.Life-threatening rashes

Question 13.13. The role of the NP in the use of herbal medication is to: (Points : 1)
a.Maintain competence in the prescribing of common herbal remedies b.Recommend common over-the-counter herbs to patients.Advanced Pharmacology Exam Assignment Papers.

c.Educate patients and guide them to appropriate sources of care d.Encourage patients to not use herbal therapy due to the documented dangers

Question 14.14. According to Traditional Chinese Medicine, if a person who has a fever is given an herb that is cooling in nature, such as golden seal, the patient’s illness will: (Points : 1)
a. Get worse.Advanced Pharmacology Exam Assignment Papers.

b.Get better

c.Not be adequately treated

d.Need additional herbs to treat the yang

Question 15.15. Michael asks you about why some drugs are over-the-counter and some are prescription. You explain that in order for a drug to be approved for over-the-counter use the drug must: (Points : 1).Advanced Pharmacology Exam Assignment Papers.
a. Be safe and labeled for appropriate use

b.Have a low potential for abuse or misuse

c.Be taken for a condition the patient can reliably self-diagnose

d.All of the above

Question 16.16. In the United States, over-the-counter drugs are regulated by: (Points : 1)
a. No one, there is no oversight for over-the-counter medications

b.The U.S. Food and Drug Administration Center for Drug Evaluation and Research.Advanced Pharmacology Exam Assignment Papers.

c.The Drug Enforcement Administration

d.MedWatch

Question 17.17. As drugs near the end of their patent, pharmaceutical companies may apply for the drug to change to over-the-counter status in order to: (Points : 1)
a.Get a new patent for the over-the-counter form of the drug

b.Lower the costs, since most prescription benefit plans do not cover generics

c.Market the drug to a whole new population, as they are able to market to patients instead of just providers

d.Continue to make large profits from their blockbuster brand-name drug

Question 18.18. When obtaining a drug history from Harold, he gives you a complete list of his prescription medications. He denies taking any other drugs, but you find that he occasionally takes aspirin for his arthritis flare ups. This is an example of: (Points : 1)
a.His appropriately only telling you about his regularly prescribed medications.Advanced Pharmacology Exam Assignment Papers.

b.His hiding information regarding his inappropriate use of aspirin from you

c.A common misconception that intermittently taken over-the counter medications are not an important part of his drug history

d.A common misuse of over-the-counter aspirin

Question 19.19. When prescribing a tetracycline or quinolone antibiotic it is critical to instruct the patient: (Points : 1)

a.Not to take their regularly prescribed medications while on these antibiotics.Advanced Pharmacology Exam Assignment Papers.

b. Regarding the need for lots of acidic foods and juices, such as orange juice, to enhance absorption

c.Not to take antacids while on these medications, as the antacid decreases absorption

d.That there are no drug interactions with these antibiotics

Question 20.20. Sadie’s adult daughter reports that when Sadie (age 84 years) takes Tylenol PM (acetaminophen and diphenhydramine) to help her sleep she has “strange dreams” including wandering and thinking she is at her childhood home. You understand: (Points : 1)
a.This is a sign of early dementia and she should undergo cognitive testing b.Sadie is not taking an effective dose to help her stay asleep.Advanced Pharmacology Exam Assignment Papers.

c.Sadie is exhibiting signs of an allergic reaction to the diphenhydramine in the Tylenol PM

d.Delirium is a common adverse reaction seen when elderly patients take diphenhydramine.Advanced Pharmacology Exam Assignment Papers.